Cinnarizine
Generic Details
Generic Name
Cinnarizine
Other Names
- Stugeron
- Stunarone
- Cinirin
Drug Class
- Antihistamine
- Antiemetic
- Calcium channel blocker
Chemical Formula
C26H28N2
Molecular Weight
368.51 g/mol
Mechanism of Action
- Blocks calcium channels
- Antagonizes histamine H1 receptors
- Reduces vestibular stimulation
Indications
- Motion sickness
- Vertigo
- Meniere's disease
Common Dosage Forms
- Tablet
- Capsule
Typical Dosage
- 25-75 mg per day in divided doses
Pediatric Dosage
- Not recommended for children under 12 years
Geriatric Dosage
- Lower starting dose may be required in elderly patients
Side Effects
- Drowsiness
- Dry mouth
- Headache
- Blurred vision
Contraindications
- Hypersensitivity to cinnarizine
- Parkinson's disease
Pregnancy Category
- Not recommended during pregnancy
Lactation Safety
- Caution advised, consult healthcare provider
Drug Interactions
- Avoid concurrent use with other sedatives or CNS depressants
Overdose Symptoms
- Excessive sedation
- Hypotension
- Extrapyramidal effects
Antidote for Overdose
- Symptomatic and supportive treatment
Storage Conditions
- Store at room temperature away from moisture and heat
Pharmacokinetics
- Absorption: Well absorbed from the gastrointestinal tract
- Distribution: Extensively distributed in the body
- Metabolism: Metabolized in the liver
- Excretion: Eliminated mainly through urine and feces
Precautions
- Use caution when driving or operating machinery
- Avoid alcohol consumption
Warnings
- May cause drowsiness, avoid activities requiring alertness
Others
- It is not recommended for use in patients with a history of extrapyramidal side effects