Cinnarizine + Dimenhydrinate
Generic Details
Generic Name
Cinnarizine-Dimenhydrinate
Other Names
- Cinarizine-Diphenhydramine
- Cinnozin
- Dramine
- Marezine
Drug Class
- Antiemetic
- Antivertigo
- Antihistamine
Chemical Formula
C26H28N2O3(C21H26ClN3O3)2
Molecular Weight
995.14 g/mol
Mechanism of Action
- Blocks H1 histamine receptors
- Calcium channel blocking activity
Indications
- Motion sickness
- Vertigo
- Nausea and vomiting associated with Meniere's disease
Common Dosage Forms
- Tablet
- Capsule
Typical Dosage
- 25 mg cinnarizine + 50 mg dimenhydrinate every 8 hours
Pediatric Dosage
- Consult a pediatrician for appropriate dosing
Geriatric Dosage
- Dosage adjustments may be needed, consult a healthcare provider
Side Effects
- Drowsiness
- Dry mouth
- Blurred vision
- Constipation
Contraindications
- Hypersensitivity to cinnarizine, dimenhydrinate, or related drugs
- Narrow-angle glaucoma
Pregnancy Category
- Category C - Risk cannot be ruled out
Lactation Safety
- Use with caution, consult healthcare provider
Drug Interactions
- Avoid alcohol as it may increase drowsiness
- May enhance the effects of other sedatives
Overdose Symptoms
- Extreme drowsiness
- Confusion
- Seizures
Antidote for Overdose
- Supportive care and symptomatic treatment
Storage Conditions
- Store at room temperature away from moisture and heat
Pharmacokinetics
- Absorption: Rapidly absorbed from the gastrointestinal tract
- Distribution: Widely distributed in the body, crosses the blood-brain barrier
- Metabolism: Metabolized extensively in the liver
- Excretion: Primarily excreted in urine
Precautions
- Use caution when operating machinery or driving due to potential drowsiness
Warnings
- May cause drowsiness, avoid activities requiring mental alertness until response to medication is known
Others
- Avoid prolonged exposure to sunlight as it may increase photosensitivity