Clindamycin + Tretinoin
Generic Details
Generic Name
Clindamycin-Tretinoin
Other Names
- Veltin
- Ziana
Drug Class
- Topical combination medication
Chemical Formula
Molecular Weight
Mechanism of Action
- Combination of an antibiotic (clindamycin) and a retinoid (tretinoin) that work together to treat acne
Indications
- Treatment of acne vulgaris
Common Dosage Forms
- Topical gel
Typical Dosage
- Apply a thin layer to affected areas once daily in the evening
Pediatric Dosage
- Safety and efficacy not established in pediatric patients
Geriatric Dosage
- Consider dose adjustment in elderly patients
Side Effects
- Common side effects include dryness, peeling, skin irritation, burning sensation, erythema (redness), and itching at the application site
Contraindications
- Hypersensitivity to clindamycin, tretinoin, lincomycin, or any component of the formulation
Pregnancy Category
- Category C - Animal reproduction studies have shown an adverse effect on the fetus and there are no adequate and well-controlled studies in humans
Lactation Safety
- Limited data available; use with caution or avoid
Drug Interactions
- Caution with concomitant use of other potentially irritating topical products
Overdose Symptoms
- Unlikely with topical application; seek medical attention if ingested
Antidote for Overdose
- Not applicable for topical overdose
Storage Conditions
- Store at controlled room temperature
Pharmacokinetics
- Absorption: Absorbed through the skin
- Distribution: Not well defined
- Metabolism: Tretinoin is metabolized to its active form in the skin
- Excretion: Mainly through the urine
Precautions
- Avoid contact with eyes, mouth, angles of the nose, and mucous membranes
Warnings
- For external use only; avoid sunlight exposure due to increased sensitivity to UV rays