Clobazam
Generic Details
Generic Name
Clobazam
Other Names
- Frisium
- Onfi
Drug Class
- Benzodiazepine
Chemical Formula
C16H13ClN2O2
Molecular Weight
300.74 g/mol
Mechanism of Action
- Enhances the effect of gamma-aminobutyric acid (GABA)
Indications
- Epilepsy
- Anxiety disorders
Common Dosage Forms
- Tablet
Typical Dosage
- 10-20 mg once daily for adults
Pediatric Dosage
- Dose based on weight and age; to be determined by a healthcare provider
Geriatric Dosage
- Lower initial doses may be necessary due to decreased drug clearance in elderly patients
Side Effects
- Drowsiness
- Fatigue
- Dizziness
- Constipation
- Weight gain
Contraindications
- Hypersensitivity to clobazam or other benzodiazepines
- Narrow-angle glaucoma
Pregnancy Category
- C - Risk cannot be ruled out
Lactation Safety
- Limited data, caution advised
Drug Interactions
- Alcohol
- Other CNS depressants
- Fluvoxamine
Overdose Symptoms
- Drowsiness
- Confusion
- Coma
- Respiratory depression
Antidote for Overdose
- Flumazenil
Storage Conditions
- Store at room temperature away from light and moisture
Pharmacokinetics
- Absorption: Well-absorbed orally
- Distribution: Extensively distributed in the body
- Metabolism: Hepatic metabolism via CYP enzymes
- Excretion: Mainly in the urine
Precautions
- Monitor for signs of respiratory depression
- Avoid abrupt discontinuation
Warnings
- Risk of dependence and withdrawal reactions
- May cause drowsiness; caution while driving or operating machinery