Clobetasol Propionate + Neomycin Sulphate + Nystatin

Generic Details

Generic Name

Clobetasol Propionate + Neomycin Sulphate + Nystatin

Other Names

    Drug Class

    • Topical corticosteroid + Antibacterial + Antifungal combination

    Chemical Formula

    Molecular Weight

    Mechanism of Action

    • Clobetasol Propionate: Potent corticosteroid with anti-inflammatory and vasoconstrictive properties
    • Neomycin Sulphate: Bactericidal action by inhibiting protein synthesis in susceptible bacteria
    • Nystatin: Antifungal agent that binds to sterols in fungal cell membrane, leading to cell death

    Indications

    • Topical treatment of inflammatory and pruritic manifestations of corticosteroid-responsive dermatoses complicated by secondary infection caused by organisms susceptible to neomycin or nystatin

    Common Dosage Forms

    • Cream
    • Ointment
    • Lotion

    Typical Dosage

    • Apply a thin film to the affected area 2-3 times daily

    Pediatric Dosage

      Geriatric Dosage

        Side Effects

        • Burning
        • Itching
        • Irritation
        • Dryness
        • Folliculitis
        • Hypopigmentation
        • Allergic contact dermatitis
        • Secondary infections
        • Cushing syndrome

        Contraindications

        • Hypersensitivity to any component of the product
        • Perioral dermatitis
        • Skin atrophy

        Pregnancy Category

        • Clobetasol Propionate: Category C - may be used if potential benefits justify the potential risk to the fetus
        • Neomycin Sulphate: Category D - evidence of risk in humans exists
        • Nystatin: Category B - usually considered safe for use

        Lactation Safety

        • Clobetasol Propionate: Limited data, caution advised
        • Neomycin Sulphate: Excreted into breast milk, consider the importance of the drug to the mother
        • Nystatin: Poorly absorbed orally, minimal risk to the infant

        Drug Interactions

        • No significant drug interactions reported with topical use

        Overdose Symptoms

        • Extended use of corticosteroids can lead to systemic side effects such as Cushing syndrome

        Antidote for Overdose

          Storage Conditions

          • Store at room temperature away from moisture and heat

          Pharmacokinetics

          • Absorption: Clobetasol Propionate: Absorbed systemically
          • Distribution: N/A
          • Metabolism: N/A
          • Excretion: N/A

          Precautions

          • Avoid prolonged use
          • Avoid use on face, groin, or axillae
          • Do not occlude the treated area unless directed by the physician

          Warnings

          • Not for ophthalmic use
          • Do not use with occlusive dressings unless directed by the physician
          • Discontinue if no improvement after 2 weeks

          Others

          • It is important to consult a healthcare professional before using this medication.