Clobetasol Propionate + Salicylic Acid

Generic Details

Generic Name

Clobetasol Propionate and Salicylic Acid

Other Names

  • Clobetasol and Salicylic Acid combination

Drug Class

  • Topical corticosteroid and keratolytic combination

Chemical Formula

Clobetasol Propionate: C25H32ClFO5, Salicylic Acid: C7H6O3

Molecular Weight

Clobetasol Propionate: 466.97 g/mol, Salicylic Acid: 138.12 g/mol

Mechanism of Action

  • Clobetasol - reduces inflammation and suppresses the immune response, Salicylic Acid - helps in shedding of dead skin cells

Indications

  • Psoriasis
  • Eczema
  • Dermatitis
  • Acne vulgaris

Common Dosage Forms

  • Topical cream
  • Topical ointment
  • Topical gel

Typical Dosage

  • Apply a thin layer to the affected area once or twice daily

Pediatric Dosage

  • Use under the guidance of a healthcare provider

Geriatric Dosage

  • May require dosage adjustment under healthcare provider's supervision

Side Effects

  • Skin irritation
  • Burning sensation
  • Dryness
  • Itching
  • Hypopigmentation
  • Hyperpigmentation

Contraindications

  • Hypersensitivity to clobetasol, salicylic acid, or other ingredients

Pregnancy Category

  • Category C - Consult healthcare provider before use during pregnancy

Lactation Safety

  • Use with caution while breastfeeding, consult healthcare provider

Drug Interactions

  • No significant drug interactions reported

Overdose Symptoms

  • Prolonged or excessive use may lead to systemic side effects of corticosteroids

Antidote for Overdose

  • No specific antidote, discontinue use and seek medical attention

Storage Conditions

  • Store at room temperature away from moisture and heat

Pharmacokinetics

  • Absorption: Topical application leads to systemic absorption of clobetasol propionate
  • Distribution: Following absorption, clobetasol is distributed extensively in the body
  • Metabolism: Clobetasol undergoes hepatic metabolism
  • Excretion: Excreted mainly via urine

Precautions

  • Avoid prolonged use on the face or genital area
  • Do not cover the treated area with airtight dressings unless directed by the healthcare provider

Warnings

  • Prolonged use can lead to skin thinning and systemic side effects

Others

  • Always follow the prescribed dosage and application instructions, do not exceed recommended duration of use