Clobetasol Propionate

Generic Details

Generic Name

Clobetasol Propionate

Other Names

  • Clobex
  • Olux
  • Temovate

Drug Class

  • Corticosteroid

Chemical Formula

C25H32ClFO5

Molecular Weight

466.97 g/mol

Mechanism of Action

  • It exerts its anti-inflammatory, antipruritic, and vasoconstrictive actions by binding to cytoplasmic glucocorticoid receptors.

Indications

  • Psoriasis
  • Eczema
  • Dermatitis
  • Lichen Planus

Common Dosage Forms

  • Cream
  • Ointment
  • Solution
  • Foam

Typical Dosage

  • Apply a thin layer to the affected area once daily

Pediatric Dosage

  • Consult healthcare provider for appropriate dosing

Geriatric Dosage

  • May require lower doses due to increased risk of skin thinning and other side effects

Side Effects

  • Skin irritation
  • Burning
  • Itching
  • Dryness
  • Redness
  • Folliculitis

Contraindications

  • Hypersensitivity to clobetasol propionate or any component of the formulation

Pregnancy Category

  • Category C - Animal reproduction studies have shown an adverse effect on the fetus and there are no adequate and well-controlled studies in humans

Lactation Safety

  • Use with caution, minimal amounts of corticosteroids may be absorbed and excreted in breast milk

Drug Interactions

  • No significant drug interactions reported

Overdose Symptoms

  • Topical corticosteroid overdose is rare but may lead to increased risk of systemic effects

Antidote for Overdose

  • No specific antidote, treatment is symptomatic and supportive

Storage Conditions

  • Store at controlled room temperature between 20°C to 25°C (68°F to 77°F)

Pharmacokinetics

  • Absorption: Well absorbed through the skin
  • Distribution: Protein binding is high
  • Metabolism: Metabolized in the liver
  • Excretion: Excreted mainly in the urine

Precautions

  • Avoid use on the face, groin, or axillae unless directed by a healthcare provider
  • Do not use occlusive dressings unless directed

Warnings

  • Prolonged use may lead to skin atrophy
  • Discontinue if no improvement is seen after a few weeks

Others

  • Avoid abrupt discontinuation - taper off the medication slowly to prevent rebound effects