Clobetasone Butyrate

Generic Name

clobetasone-butyrate

Other Names

• Eumovate

Drug Class

• Corticosteroid

Chemical Formula

C27H37FO6

Molecular Weight

476.58 g/mol

Mechanism of Action

• Clobetasone-butyrate binds to glucocorticoid receptors and exerts anti-inflammatory, anti-pruritic, and vasoconstrictive effects.

Indications

• Eczema
• Dermatitis
• Psoriasis
• Allergic reactions on the skin

Common Dosage Forms

• Cream
• Ointment

Typical Dosage

• Apply a thin layer to the affected skin area 1-2 times daily

Pediatric Dosage

• Use in children should be under the supervision of a healthcare provider

Geriatric Dosage

• May require lower doses due to age-related changes in skin thickness and absorption

Side Effects

• Skin irritation
• Burning sensation
• Itching
• Redness
• Dryness

Contraindications

• Hypersensitivity to clobetasone-butyrate or any components of the formulation

Pregnancy Category

• C - Use with caution if benefits outweigh risks

Lactation Safety

• Safe to use, but avoid application on areas close to the breast during breastfeeding

Drug Interactions

• No significant drug interactions reported

Overdose Symptoms

• Unlikely due to topical application, systemic effects are rare

Antidote for Overdose

• Not applicable for topical corticosteroids

Storage Conditions

• Store at room temperature away from moisture and heat

Pharmacokinetics

• Absorption: Well absorbed through the skin
• Distribution: Enters systemic circulation and binds to plasma proteins
• Metabolism: Metabolized in the liver
• Excretion: Excreted primarily in the urine

Precautions

• Avoid use on the face, groin, or underarms for prolonged periods
• Do not cover the treated area with airtight dressings unless directed by a healthcare provider

Warnings

• Discontinue use if skin irritation or allergic reaction occurs
• Avoid contact with eyes