Clopidogrel Bisulphate
Generic Details
Generic Name
Clopidogrel-bisulphate
Other Names
- Plavix
Drug Class
- Antiplatelet agent
Chemical Formula
C16H16ClNO2S
Molecular Weight
321.815 g/mol
Mechanism of Action
- Inhibits platelet aggregation by blocking the P2Y12 adenosine diphosphate receptor
Indications
- Prevention of blood clots in patients with a recent heart attack, stroke, or peripheral vascular disease
Common Dosage Forms
- Tablet
Typical Dosage
- 75 mg once daily
Pediatric Dosage
- Not established
Geriatric Dosage
- Use with caution due to increased risk of bleeding
Side Effects
- Bleeding, gastrointestinal ulcers, neutropenia, thrombotic thrombocytopenic purpura
Contraindications
- Active bleeding, severe liver disease
Pregnancy Category
- Category B
Lactation Safety
- Compatible with breastfeeding
Drug Interactions
- Increased risk of bleeding with NSAIDs, heparin, warfarin
Overdose Symptoms
- Increased bleeding risk
Antidote for Overdose
- Platelet transfusion if necessary
Storage Conditions
- Store at room temperature away from moisture and heat
Pharmacokinetics
- Absorption: Rapidly absorbed after oral administration
- Distribution: Protein bound, primarily circulates in plasma
- Metabolism: Hepatic, converted to an active metabolite
- Excretion: Renal and fecal elimination
Precautions
- Monitor for signs of bleeding, avoid activities that may increase bleeding risk
Warnings
- Discontinue use prior to surgery if possible to reduce bleeding risk