Clotrimazole (Topical)

Generic Name

Clotrimazole Topical

Other Names

• Lotrimin
• Canesten

Drug Class

• Antifungal

Chemical Formula

C22H17ClN2

Molecular Weight

344.84 g/mol

Mechanism of Action

• Inhibits ergosterol synthesis in fungal cell membranes

Indications

• Treatment of fungal skin infections such as athlete's foot, ringworm, jock itch, and yeast infections

Common Dosage Forms

• Cream
• Lotion
• Ointment
• Powder
• Solution
• Spray

Typical Dosage

• Apply a thin layer to the affected area twice daily

Pediatric Dosage

• Consult healthcare provider for appropriate dosage

Geriatric Dosage

• Adjust dosage according to individual patient needs

Side Effects

• Skin irritation
• Burning
• Itching
• Rash

Contraindications

• Hypersensitivity to clotrimazole or any component of the formulation

Pregnancy Category

• Category B - No evidence of risk in humans

Lactation Safety

• Safe to use while breastfeeding

Drug Interactions

• No significant drug interactions reported

Overdose Symptoms

• Unlikely with topical use

Antidote for Overdose

• N/A

Storage Conditions

• Store at room temperature away from moisture and heat

Pharmacokinetics

• Absorption: Minimal systemic absorption
• Distribution: Not well defined
• Metabolism: Hepatic metabolism
• Excretion: Mainly excreted in feces

Precautions

• Avoid contact with eyes
• Not for internal use

Warnings

• For external use only
• Discontinue use if irritation occurs

Others

• Avoid using tight-fitting diapers or plastic pants on a child being treated in the diaper area