Clotrimazole + Hydrocortisone

Generic Details

Generic Name

Clotrimazole-Hydrocortisone

Other Names

  • Clotrimazole and Hydrocortisone Cream

Drug Class

  • Antifungal and Corticosteroid Combination

Chemical Formula

Molecular Weight

Mechanism of Action

  • Clotrimazole - Antifungal: Inhibits the synthesis of ergosterol in the fungal cell membrane.
  • Hydrocortisone - Corticosteroid: Anti-inflammatory and immunosuppressive effects by binding to glucocorticoid receptors.

Indications

  • Topical treatment of fungal skin infections complicated by inflammatory dermatitis

Common Dosage Forms

  • Cream

Typical Dosage

  • Apply a thin layer to the affected area 2-3 times daily

Pediatric Dosage

  • Use with caution and follow pediatrician's advice

Geriatric Dosage

  • Use with caution and follow healthcare provider's recommendations

Side Effects

  • Burning
  • Itching
  • Irritation at the application site
  • Allergic reactions

Contraindications

  • Hypersensitivity to clotrimazole or hydrocortisone

Pregnancy Category

  • Category C - Consult healthcare provider before use

Lactation Safety

  • Limited data available, consult healthcare provider before use

Drug Interactions

  • Minimal systemic absorption limits interactions

Overdose Symptoms

  • Unlikely with topical application

Antidote for Overdose

  • N/A

Storage Conditions

  • Store at room temperature away from moisture and heat

Pharmacokinetics

  • Absorption: Limited systemic absorption
  • Distribution: Not well defined
  • Metabolism: Metabolized in the liver
  • Excretion: Primarily in the urine

Precautions

  • Avoid contact with eyes
  • Not for use on large areas of skin or for prolonged periods

Warnings

  • Discontinue if irritation or sensitization occurs
  • Do not use on broken or infected skin

Others

  • Always consult a healthcare provider before use.