Aceclofenac
Generic Details
Generic Name
Aceclofenac
Other Names
- Proflam
- Airtal
- Preferan
Drug Class
- Nonsteroidal anti-inflammatory drug (NSAID)
Chemical Formula
C16H13Cl2NO4
Molecular Weight
354.185 g/mol
Mechanism of Action
- Inhibition of cyclooxygenase enzyme (COX)
Indications
- Pain and inflammation in rheumatoid arthritis
- Osteoarthritis
- Ankylosing spondylitis
Common Dosage Forms
- Tablet
- Capsule
Typical Dosage
- 100 mg twice daily
Pediatric Dosage
- Not recommended for children under 18 years
Geriatric Dosage
- Dose adjustment may be required in elderly patients
Side Effects
- Gastrointestinal disturbances
- Dizziness
- Headache
- Skin rashes
Contraindications
- Hypersensitivity to NSAIDs
- Active peptic ulcer disease
- Severe heart failure
Pregnancy Category
- Category B - Caution advised, consult healthcare provider
Lactation Safety
- Limited data available, consult healthcare provider
Drug Interactions
- Avoid concomitant use with other NSAIDs
- May interact with anticoagulants and diuretics
Overdose Symptoms
- Nausea
- Vomiting
- Abdominal pain
Antidote for Overdose
- Supportive care and symptomatic treatment
Storage Conditions
- Store at room temperature (15-30°C)
- Protect from light and moisture
Pharmacokinetics
- Absorption: Well absorbed from the gastrointestinal tract
- Distribution: Highly protein-bound
- Metabolism: Undergoes hepatic metabolism
- Excretion: Primarily excreted in urine
Precautions
- Monitor renal function in patients with renal impairment
- Consider gastroprotection in high-risk patients
Warnings
- May increase risk of cardiovascular events
- Can cause gastrointestinal bleeding
Others
- Avoid prolonged use
- Discontinue if allergic reactions occur