Conjugated Estrogen (Tablet)
Generic Details
Generic Name
Conjugated Estrogen Tablet
Other Names
- Premarin
Drug Class
- Estrogen
Chemical Formula
C18H24O2
Molecular Weight
268.381 g/mol
Mechanism of Action
- Conjugated estrogens mimic the actions of endogenous estrogens by binding to estrogen receptors.
Indications
- Hormone replacement therapy for menopausal symptoms
- Osteoporosis prevention and treatment
- Breast cancer treatment in select cases
- Postmenopausal vaginal symptoms
Common Dosage Forms
- Tablet
Typical Dosage
- 0.3-1.25 mg/day
Pediatric Dosage
Geriatric Dosage
Side Effects
- Nausea
- Breast tenderness
- Headache
- Vaginal bleeding
- Edema
Contraindications
- Pregnancy
- Breastfeeding
- Estrogen-dependent tumor
- Liver disease
Pregnancy Category
- X - Contraindicated in pregnancy
Lactation Safety
- Contraindicated
Drug Interactions
- Warfarin
- CYP3A4 inducers/inhibitors
Overdose Symptoms
- Nausea
- Vomiting
- Breast tenderness
Antidote for Overdose
- No specific antidote, supportive care
Storage Conditions
- Store at room temperature away from moisture and heat
Pharmacokinetics
- Absorption: Well absorbed from the gastrointestinal tract
- Distribution: Distributed widely in the body
- Metabolism: Metabolized in the liver
- Excretion: Excreted in urine and feces
Precautions
- Monitor for signs of thromboembolism
- Regular breast examinations
- Monitor lipid levels
Warnings
- Increased risk of endometrial cancer
- Cardiovascular risks in postmenopausal women
- Avoid in patients with known or suspected breast cancer
Others
- Regular gynecological evaluations are recommended during use.