Permethrin + Crotamiton
Generic Details
Generic Name
Permethrin-Crotamiton
Other Names
- Permethrin Crotamiton combination
Drug Class
- Topical antiparasitic agent
Chemical Formula
C21H20Cl2O3 - Permethrin, C16H26O2 - Crotamiton
Molecular Weight
391.29 g/mol - Permethrin, 242.38 g/mol - Crotamiton
Mechanism of Action
- Permethrin acts on the nerve cell membrane of parasites, leading to paralysis and death.
- Crotamiton has antipruritic properties and is used to relieve itching.
Indications
- Scabies
- Pediculosis (lice infestation)
Common Dosage Forms
- Topical cream
- Topical lotion
Typical Dosage
- Apply a thin layer from neck to toes and leave on for 8-14 hours (scabies)
- Repeat after 7 days if needed
Pediatric Dosage
- As per physician's recommendation based on weight and age
Geriatric Dosage
- Use with caution, dose adjustment may be required
Side Effects
- Skin irritation
- Itching or stinging at application site
- Redness or rash
Contraindications
- Hypersensitivity to permethrin or crotamiton
Pregnancy Category
- Category B - Animal studies have not demonstrated risk to the fetus but no adequate studies in pregnant women.
Lactation Safety
- Use with caution, limited data available
Drug Interactions
- No significant interactions reported
Overdose Symptoms
- Nausea
- Vomiting
- Dizziness
Antidote for Overdose
- No specific antidote, symptomatic treatment
Storage Conditions
- Store at room temperature below 30°C
Pharmacokinetics
- Absorption: Permethrin: Minimal systemic absorption after topical application
- Distribution: Both agents may distribute into breast milk
- Metabolism: Permethrin: Metabolized in the liver
- Excretion: Permethrin: Excreted in urine and feces
Precautions
- Avoid contact with eyes or mucous membranes
- Do not use on broken skin
Warnings
- For external use only
- Consult healthcare provider before use in pregnancy or lactation
Others
- Complete the full course as directed by the healthcare provider