Crotamiton

Generic Details

Generic Name

Crotamiton

Other Names

  • Eurax
  • Eurax Cream
  • Eurax Lotion

Drug Class

  • Scabicides and Pediculicides

Chemical Formula

C13H17NO

Molecular Weight

203.28 g/mol

Mechanism of Action

  • Exact mechanism is unknown; believed to act as a CNS depressant in mites and lice

Indications

  • Treatment of scabies
  • Relief of itching associated with scabies and other skin conditions

Common Dosage Forms

  • Cream
  • Lotion

Typical Dosage

  • Apply to the entire body from the chin down once daily for 2 consecutive days

Pediatric Dosage

  • As directed by a healthcare provider

Geriatric Dosage

  • Use with caution, dosage adjustments may be necessary based on individual health status

Side Effects

  • Burning
  • Stinging
  • Irritation at application site
  • Allergic reactions

Contraindications

  • Hypersensitivity to crotamiton or any component of the formulation

Pregnancy Category

  • Category C: Animal reproduction studies have shown an adverse effect on the fetus

Lactation Safety

  • Unknown if excreted in breast milk; use caution or avoid during breastfeeding

Drug Interactions

  • No significant drug interactions reported

Overdose Symptoms

  • Excessive topical use may lead to systemic toxicity

Antidote for Overdose

  • No specific antidote; discontinue use and provide supportive care

Storage Conditions

  • Store at room temperature away from moisture and heat

Pharmacokinetics

  • Absorption: Minimal absorption through the skin
  • Distribution: Not well studied
  • Metabolism: Not well studied
  • Excretion: Primarily through urine

Precautions

  • Avoid contact with eyes and mucous membranes
  • Not for oral use
  • Avoid in children under 2 months of age

Warnings

  • For external use only
  • Not for ophthalmic use
  • Consult healthcare provider before use in pregnancy or breastfeeding

Others

  • Do not use on open wounds or broken skin