Cyclobenzaprine Hydrochloride
Generic Details
Generic Name
Cyclobenzaprine Hydrochloride
Other Names
- Flexeril
- Fexmid
- Amrix
Drug Class
- Muscle Relaxant
Chemical Formula
C20H21N
Molecular Weight
275.39 g/mol
Mechanism of Action
- Acts on the central nervous system to relax muscles
Indications
- Muscle spasms
- Musculoskeletal pain
Common Dosage Forms
- Tablet
- Extended-release capsule
Typical Dosage
- 5-10 mg three times a day
Pediatric Dosage
- Not recommended for children under 15 years
Geriatric Dosage
- Start with lower doses due to increased risk of side effects
Side Effects
- Drowsiness
- Dry mouth
- Dizziness
- Fatigue
Contraindications
- Hypersensitivity to cyclobenzaprine
- Recent heart attack
- Heart rhythm disorders
Pregnancy Category
- Category B - No evidence of risk in humans
Lactation Safety
- Use with caution, consult healthcare provider
Drug Interactions
- MAO inhibitors
- SSRIs
- Tricyclic antidepressants
Overdose Symptoms
- Extreme drowsiness
- Confusion
- Hallucinations
- Seizures
Antidote for Overdose
- Activated charcoal
- Supportive care
Storage Conditions
- Store at room temperature away from moisture and heat
Pharmacokinetics
- Absorption: Rapidly absorbed from the gastrointestinal tract
- Distribution: Highly protein-bound
- Metabolism: Hepatic metabolism via CYP3A4
- Excretion: Primarily renal excretion
Precautions
- Caution in patients with liver or kidney impairment
- Avoid alcohol consumption
Warnings
- May cause drowsiness, avoid driving or operating machinery