Danazol
Generic Details
Generic Name
Danazol
Other Names
- Danocrine
Drug Class
- Synthetic androgen
Chemical Formula
C22H27NO2
Molecular Weight
337.46 g/mol
Mechanism of Action
- Danazol suppresses the pituitary-ovarian axis, reducing estrogen production and inhibiting the midcycle surge of LH and FSH.
Indications
- Treatment of endometriosis
- Hereditary angioedema
- Fibrocystic breast disease
Common Dosage Forms
- Capsules
Typical Dosage
- Endometriosis: 200-800 mg daily in divided doses
- Angioedema: 200 mg 2-3 times daily
Pediatric Dosage
- Not established
Geriatric Dosage
- Dosage adjustments may be required
Side Effects
- Weight gain
- Acne
- Oily skin
- Edema
- Hot flashes
- Voice changes
- Irregular menstrual periods
Contraindications
- Pregnancy
- Thromboembolic disease
- Porphyria
- Undiagnosed vaginal bleeding
- Hepatic dysfunction
Pregnancy Category
- Pregnancy Category X
Lactation Safety
- Not recommended during breastfeeding
Drug Interactions
- Warfarin
- Carbamazepine
- Cyclosporine
Overdose Symptoms
- Nausea
- Vomiting
- Headache
Antidote for Overdose
- There is no specific antidote; treatment is supportive.
Storage Conditions
- Store at room temperature away from moisture and heat
Pharmacokinetics
- Absorption: Well absorbed orally
- Distribution: Highly protein-bound
- Metabolism: Metabolized in the liver
- Excretion: Primarily renal
Precautions
- Monitor liver function tests regularly
- Consider risk of androgenic side effects
Warnings
- Risk of virilization in females
- May increase LDL cholesterol levels
Others
- Danazol should only be used for the conditions indicated under medical supervision.