Dapoxetine Hydrochloride

Generic Details

Generic Name

Dapoxetine Hydrochloride

Other Names

  • Priligy

Drug Class

  • Selective Serotonin Reuptake Inhibitors (SSRIs)

Chemical Formula

C21H23NO

Molecular Weight

305.42 g/mol

Mechanism of Action

  • Dapoxetine is a short-acting SSRI with a primary mechanism of action as a serotonin transporter inhibitor.

Indications

  • Treatment of premature ejaculation in men aged 18-64 years.

Common Dosage Forms

  • Tablet

Typical Dosage

  • The typical starting dose is 30 mg, which can be increased to 60 mg if needed.

Pediatric Dosage

  • Not recommended for use in children under 18 years of age.

Geriatric Dosage

  • Use with caution in elderly patients, starting at the lower end of the dosing range.

Side Effects

  • Common side effects may include nausea, dizziness, headache, and diarrhea.

Contraindications

  • Contraindicated in patients with a history of mania/hypomania, severe hepatic impairment, concomitant use with monoamine oxidase inhibitors (MAOIs), and those taking thioridazine.

Pregnancy Category

  • Category C - Safety in pregnancy has not been established; avoid its use in pregnant women.

Lactation Safety

  • Limited data available; use with caution in breastfeeding women.

Drug Interactions

  • Avoid concomitant use with MAOIs, thioridazine, or other SSRIs due to potential for serious drug interactions.

Overdose Symptoms

  • Symptoms of overdose may include serotonin syndrome, seizures, and prolonged QT interval.

Antidote for Overdose

  • There is no specific antidote for dapoxetine overdose; symptomatic and supportive treatment is recommended.

Storage Conditions

  • Store at room temperature away from moisture and heat.

Pharmacokinetics

  • Absorption: Rapidly absorbed after oral administration.
  • Distribution: Extensively distributed in the body.
  • Metabolism: Primarily metabolized by the liver via CYP2D6 and CYP3A4.
  • Excretion: Mainly excreted in the urine.

Precautions

  • Use with caution in patients with a history of orthostatic hypotension, bipolar disorder, or seizure disorders.

Warnings

  • May cause syncope and lower seizure threshold; advise patients to avoid driving or operating machinery if affected.

Others

  • Dapoxetine should not be used as an antidepressant medication; it is specifically indicated for premature ejaculation.