Cyproterone Acetate + Ethinyl Estradiol
Generic Details
Generic Name
Cyproterone Acetate/Ethinyl Estradiol
Other Names
- Diane-35
- Dianette
- Clairette
Drug Class
- Combination contraceptive
- Antiandrogen
Chemical Formula
C24H29ClO4 / C20H24O2
Molecular Weight
416.94 g/mol / 296.4 g/mol
Mechanism of Action
- Suppression of ovulation
- Antiandrogenic effects
Indications
- Hormonal acne in women
- Hirsutism
- Androgenic alopecia
- Contraception in women with androgen-related conditions
Common Dosage Forms
- Oral tablet
Typical Dosage
- One tablet daily for 21 days, followed by a 7-day break
Pediatric Dosage
Geriatric Dosage
Side Effects
- Nausea
- Headache
- Breast tenderness
- Irregular bleeding
- Mood changes
- Weight changes
Contraindications
- History of thromboembolic disorders
- Liver disease
- Breast cancer
Pregnancy Category
- X - Contraindicated in pregnancy
Lactation Safety
- Not recommended during breastfeeding
Drug Interactions
- Antibiotics (e.g., Rifampicin)
- Antiepileptics (e.g., Carbamazepine)
- St. John's Wort
Overdose Symptoms
- Nausea
- Vomiting
- Vaginal bleeding
Antidote for Overdose
- No specific antidote, symptomatic treatment
Storage Conditions
- Store at room temperature (20-25°C)
- Protect from light and moisture
Pharmacokinetics
- Absorption: Well absorbed after oral administration
- Distribution: Highly bound to plasma proteins
- Metabolism: Metabolized in the liver
- Excretion: Excreted in urine and feces
Precautions
- Monitor blood pressure
- Monitor liver function tests
- Regular gynecological examinations
Warnings
- Increased risk of thromboembolism
- Increased risk of liver tumors
Others
- May be used off-label for transgender hormone therapy