Deflazacort

Generic Details

Generic Name

Deflazacort

Other Names

  • Calcort
  • Emflaza

Drug Class

  • Corticosteroid

Chemical Formula

C25H31NO6

Molecular Weight

441.52 g/mol

Mechanism of Action

  • Deflazacort is a glucocorticoid that acts through the activation of glucocorticoid receptors.

Indications

  • Deflazacort is indicated for conditions that require anti-inflammatory or immunosuppressive effects such as autoimmune conditions, allergic reactions, asthma, and inflammatory diseases.

Common Dosage Forms

  • Tablet
  • Oral suspension

Typical Dosage

  • Adults: 6-90 mg/day in divided doses
  • Children: 0.25-1.5 mg/kg/day in divided doses

Pediatric Dosage

  • Dosage in children varies based on weight and condition being treated. It is important to consult a healthcare provider for the appropriate dosage.

Geriatric Dosage

  • Dosage may need to be adjusted in elderly patients based on their overall health status and potential drug interactions.

Side Effects

  • Common side effects include weight gain, fluid retention, increased appetite, mood changes, and gastrointestinal disturbances.

Contraindications

  • Hypersensitivity to deflazacort, systemic fungal infections, and live vaccines administration during therapy.

Pregnancy Category

  • Deflazacort is classified as Pregnancy Category C - Risk cannot be ruled out.

Lactation Safety

  • Use with caution during lactation as it may pass into breast milk and affect the infant.

Drug Interactions

  • Deflazacort may interact with anticoagulants, antidiabetic drugs, and immunosuppressants, among others.

Overdose Symptoms

  • Symptoms of overdose may include Cushing's syndrome, increased intracranial pressure, and electrolyte disturbances.

Antidote for Overdose

  • There is no specific antidote for deflazacort overdose; treatment is symptomatic and supportive.

Storage Conditions

  • Store at room temperature away from moisture and heat.

Pharmacokinetics

  • Absorption: Well-absorbed orally
  • Distribution: Widely distributed in the body
  • Metabolism: Metabolized in the liver
  • Excretion: Excreted mainly in the urine

Precautions

  • Monitor for signs of infection, monitor blood glucose levels in diabetic patients, and use with caution in patients with a history of psychiatric disorders.

Warnings

  • Long-term use of deflazacort can lead to adrenal suppression, increased susceptibility to infections, and osteoporosis. Taper off the medication gradually to avoid adrenal insufficiency.

Others

  • It is important to follow the dosage schedule provided by the healthcare provider to maximize the benefits of deflazacort therapy.