Monosemicarbazone Adrenochrome
Generic Details
Generic Name
Monosemicarbazone-Adrenochrome
Other Names
- Semilac
- Adroxon
Drug Class
- Hematopoietic agents
Chemical Formula
C9H12N4O2
Molecular Weight
208.22 g/mol
Mechanism of Action
- Stimulates the production of red blood cells (erythropoiesis)
Indications
- Treatment of anemia
- Enhancing erythropoiesis
Common Dosage Forms
- Tablet
- Injection
Typical Dosage
- 50-100 mg orally once daily
Pediatric Dosage
- Consult pediatric hematologist for appropriate dosage
Geriatric Dosage
- Dosage adjustment may be required based on renal function
Side Effects
- Gastrointestinal disturbances
- Hypersensitivity reactions
- Hematological complications
Contraindications
- Hypersensitivity to the drug
- Severe renal impairment
Pregnancy Category
- Use with caution in pregnancy
Lactation Safety
- Consider discontinuing the drug while breastfeeding
Drug Interactions
- None reported
Overdose Symptoms
- Hyperviscosity syndrome
- Thromboembolic events
Antidote for Overdose
- No specific antidote, manage symptoms supportively
Storage Conditions
- Store at room temperature away from moisture and heat
Pharmacokinetics
- Absorption: Well-absorbed orally
- Distribution: Distributed widely in the body
- Metabolism: Metabolized in the liver
- Excretion: Excreted mainly in urine
Precautions
- Monitor hemoglobin levels regularly
- Use with caution in patients with renal impairment
Warnings
- Discontinue if signs of hypersensitivity appear
- Monitor for signs of thromboembolic events
Others
- May cause urine discoloration to pink or red