Dexibuprofen
Generic Details
Generic Name
Dexibuprofen
Other Names
- Dex-ibuprofen
Drug Class
- Nonsteroidal Anti-Inflammatory Drug (NSAID)
Chemical Formula
C18H19O3
Molecular Weight
for C18H19O3: 295.34 g/mol
Mechanism of Action
- Inhibits the enzyme cyclooxygenase (COX), leading to a reduction in prostaglandin synthesis which plays a role in inflammation, pain, and fever.
Indications
- Pain relief
- Inflammation reduction
Common Dosage Forms
- Tablet
- Capsule
Typical Dosage
- 200-400 mg every 4-6 hours as needed for pain relief
Pediatric Dosage
- Safety and efficacy not established in pediatric patients
Geriatric Dosage
- Lower doses may be required due to age-related changes in metabolism and excretion
Side Effects
- Gastrointestinal upset (nausea, indigestion)
- Headache
- Dizziness
- Rash
Contraindications
- History of allergic reactions to NSAIDs
- Peptic ulcer disease
- Severe kidney impairment
Pregnancy Category
- Category C - Risk cannot be ruled out
Lactation Safety
- Limited data available, caution advised. Preferable to avoid.
Drug Interactions
- Anticoagulants (increased risk of bleeding)
- ACE Inhibitors (reduced effectiveness of blood pressure control)
Overdose Symptoms
- Nausea
- Vomiting
- Abdominal pain
- Drowsiness
Antidote for Overdose
- Supportive care and symptomatic treatment
Storage Conditions
- Store at room temperature away from moisture and heat.
Pharmacokinetics
- Absorption: Rapidly absorbed from the gastrointestinal tract
- Distribution: Widely distributed in the body
- Metabolism: Undergoes hepatic metabolism
- Excretion: Excreted mainly in the urine
Precautions
- Use with caution in patients with a history of peptic ulcer disease or gastrointestinal bleeding
Warnings
- May increase the risk of heart attack or stroke, especially with long-term use or in high doses
Others
- Dexibuprofen is the pharmacologically active R-enantiomer of ibuprofen.