Dextromethorphan + Pseudoephedrine + Triprolidine
Generic Details
Generic Name
dextromethorphan-pseudoephedrine-triprolidine
Other Names
- DPT
- Dextrocor
- Actifed DM
Drug Class
- Upper respiratory combinations
Chemical Formula
Molecular Weight
Mechanism of Action
- Dextromethorphan: acts on the cough center in the medulla oblongata
- Pseudoephedrine: alpha-adrenergic agonist causing vasoconstriction in the nasal mucosa
- Triprolidine: competes with histamine for H1-receptor sites
Indications
- Relief of cough
- Nasal congestion
- Allergic rhinitis
Common Dosage Forms
- Tablet
- Syrup
Typical Dosage
- 1 tablet every 4-6 hours
- 5mL syrup every 4-6 hours
Pediatric Dosage
- Consult pediatrician for appropriate dosage based on weight and age
Geriatric Dosage
- May require dose adjustment. Consult healthcare provider.
Side Effects
- Drowsiness
- Dizziness
- Nausea
- Dry mouth
- Headache
Contraindications
- Hypersensitivity to any component
- Severe hypertension
- Severe coronary artery disease
Pregnancy Category
- Category C - consult healthcare provider
Lactation Safety
- Use caution, can pass into breast milk
Drug Interactions
- MAO inhibitors
- Other CNS depressants
- Sympathomimetics
Overdose Symptoms
- Severe dizziness
- Hallucinations
- Seizures
- Tachycardia
Antidote for Overdose
- No specific antidote, symptomatic treatment for overdose
Storage Conditions
- Store at room temperature away from moisture and heat
Pharmacokinetics
- Absorption:
- Distribution:
- Metabolism:
- Excretion:
Precautions
- Caution in patients with hypertension
- Caution in patients with prostate enlargement
Warnings
- Do not exceed recommended dosage
- May cause drowsiness, avoid driving or operating machinery
Others
- Avoid alcohol consumption while on this medication.