Dextran + Dextrose

Generic Details

Generic Name

Dextran-Dextrose

Other Names

  • Dextran with Dextrose

Drug Class

  • Parenteral nutrient

Chemical Formula

Molecular Weight

Mechanism of Action

  • Dextran provides colloidal volume expansion by virtue of its oncotic properties, while dextrose provides a source of glucose for energy.

Indications

  • Fluid volume replacement
  • Caloric and volume supply in parenteral nutrition

Common Dosage Forms

  • Injection

Typical Dosage

  • The dosage is dependent on the patient's clinical condition, weight, and age.

Pediatric Dosage

  • Dosage adjustments may be necessary based on weight and overall health status in pediatric patients.

Geriatric Dosage

  • Lower doses may be required for elderly patients with compromised renal or hepatic function.

Side Effects

  • Hypervolemia
  • Hyperglycemia
  • Electrolyte disturbances

Contraindications

  • Hypersensitivity to dextran or dextrose
  • Severe renal impairment

Pregnancy Category

  • Category C - Safety in pregnancy has not been established; benefit should outweigh risk

Lactation Safety

  • Caution advised; not extensively studied in lactating women

Drug Interactions

  • May interact with medications affecting glucose levels or electrolyte balance

Overdose Symptoms

  • Severe hyperglycemia
  • Fluid overload

Antidote for Overdose

  • Treatment is primarily supportive and symptomatic; may require fluid and electrolyte correction

Storage Conditions

  • Store at controlled room temperature (59°F to 86°F)

Pharmacokinetics

  • Absorption: N/A - Administered intravenously
  • Distribution: Dextran circulates in the plasma and increases oncotic pressure; dextrose is rapidly distributed and metabolized for energy.
  • Metabolism: Dextrose is metabolized in various tissues to provide energy.
  • Excretion: Dextran is primarily excreted unchanged by the kidneys; dextrose is metabolized and excreted via urine.

Precautions

  • Monitor patients for signs of fluid overload or hyperglycemia
  • Adjust dosage in patients with renal impairment

Warnings

  • Risk of hypersensitivity reactions including anaphylaxis
  • Use with caution in patients with diabetes

Others

  • Always consult healthcare provider for appropriate use and dosing.