Diclofenac Sodium + Lidocaine Hydrochloride
Generic Details
Generic Name
Diclofenac Sodium Lidocaine Hydrochloride
Other Names
- Diclofenac Lidocaine Hydrochloride
Drug Class
- Nonsteroidal Anti-Inflammatory Drug (NSAID)
- Local Anesthetic
Chemical Formula
Molecular Weight
Mechanism of Action
- Diclofenac: Inhibition of prostaglandin synthesis
- Lidocaine: Blockade of sodium channels
Indications
- Musculoskeletal pain
- Inflammation
- Local anesthesia
Common Dosage Forms
- Topical gel
- Topical solution
Typical Dosage
- Apply a thin layer of gel to the affected area 3-4 times daily
- Do not exceed recommended doses
Pediatric Dosage
- Consult a healthcare provider
Geriatric Dosage
- Adjust dosage based on renal function
Side Effects
- Skin irritation
- Burning sensation at the application site
- Allergic reactions
- Gastrointestinal disturbances
Contraindications
- Hypersensitivity to NSAIDs or lidocaine
- History of asthma, urticaria, or allergic-type reactions after taking aspirin or other NSAIDs
Pregnancy Category
- Category C - Consult a healthcare provider before use
Lactation Safety
- Use with caution, consult a healthcare provider
Drug Interactions
- Warfarin
- ACE Inhibitors
- Lithium
Overdose Symptoms
- Seizures
- Cardiac arrhythmias
Antidote for Overdose
- Supportive care
Storage Conditions
- Store at room temperature away from light and moisture
Pharmacokinetics
- Absorption: Varies based on the dosage form
- Distribution: Diclofenac: Enters breast milk; Lidocaine: Distributed to site of action
- Metabolism: Diclofenac: Hepatic metabolism; Lidocaine: Hepatic metabolism
- Excretion: Diclofenac: Renal excretion; Lidocaine: Renal excretion
Precautions
- Avoid contact with eyes, mucous membranes, or open wounds
- Do not cover the applied area with a bandage or heating pad
Warnings
- Avoid use in patients with a history of peptic ulcers or gastrointestinal bleeding