Diclofenac Sodium (Ophthalmic)
Generic Details
Generic Name
Diclofenac Sodium Ophthalmic
Other Names
- Voltaren Ophthalmic
Drug Class
- Nonsteroidal Anti-Inflammatory Drug (NSAID)
Chemical Formula
C14H10Cl2NNaO2
Molecular Weight
318.13 g/mol
Mechanism of Action
- Inhibits prostaglandin synthesis by interfering with the action of the enzyme cyclooxygenase
Indications
- Treatment of postoperative inflammation in patients who have undergone cataract extraction
Common Dosage Forms
- Ophthalmic Solution
Typical Dosage
- 1 drop in the affected eye(s) 4 times daily for 2 weeks
Pediatric Dosage
- Safety and effectiveness not established in children
Geriatric Dosage
- No adjustment necessary based on age
Side Effects
- Blurred vision
- Eye irritation
- Eye redness
- Watery eyes
Contraindications
- Hypersensitivity to diclofenac or other NSAIDs
- History of asthma, urticaria, or allergic-type reactions after taking aspirin or other NSAIDs
Pregnancy Category
- C - Risk cannot be ruled out
Lactation Safety
- Compatible with breastfeeding, but caution advised
Drug Interactions
- Avoid use with other ophthalmic NSAIDs to prevent increased risk of side effects
Overdose Symptoms
- Systemic effects are unlikely with ophthalmic use
Antidote for Overdose
- No specific antidote, treatment is symptomatic
Storage Conditions
- Store at 2°C to 25°C (36°F to 77°F), protect from light
Pharmacokinetics
- Absorption: Minimal systemic absorption through ocular administration
- Distribution: Limited distribution within the eye tissues
- Metabolism: Hepatic metabolism
- Excretion: Primarily via the urine
Precautions
- Use with caution in patients with a history of bleeding disorders or ocular surface diseases
Warnings
- Prolonged use may lead to ocular surface disease or corneal thinning