Dicycloverine Hydrochloride
Generic Details
Generic Name
Dicycloverine Hydrochloride
Other Names
- Dicyclomine Hydrochloride
- Bentyl
Drug Class
- Antispasmodic Agent
- Anticholinergic
Chemical Formula
C19H35NO2.HCl
Molecular Weight
345.95 g/mol
Mechanism of Action
- Blocks muscarinic receptors in the smooth muscle of the gastrointestinal tract
- Relaxes smooth muscle, relieving muscle spasms
Indications
- Irritable Bowel Syndrome (IBS)
- Functional Gastrointestinal disorders
- Colic
- Overactive Bladder
Common Dosage Forms
- Tablet
- Capsule
- Oral Solution
Typical Dosage
- 10-20 mg, three to four times daily before meals and at bedtime
Pediatric Dosage
- Consult healthcare provider for appropriate dosage
Geriatric Dosage
- Lower initial dose may be required in elderly patients
Side Effects
- Dry mouth
- Blurred vision
- Constipation
- Dizziness
- Drowsiness
Contraindications
- Hypersensitivity to dicycloverine
- Severe ulcerative colitis
- Obstructive uropathy
- Myasthenia gravis
Pregnancy Category
- C - Risk cannot be ruled out
Lactation Safety
- Caution advised; minimal excretion in breast milk reported
Drug Interactions
- Anticholinergic drugs
- Antidiarrheals
- Amantadine
Overdose Symptoms
- Confusion
- Hallucinations
- Seizures
- Tachycardia
Antidote for Overdose
- No specific antidote; symptomatic treatment
Storage Conditions
- Store at room temperature away from moisture and heat
Pharmacokinetics
- Absorption: Well absorbed from the gastrointestinal tract
- Distribution: Widely distributed in the body
- Metabolism: Metabolized in the liver
- Excretion: Excreted primarily in the urine
Precautions
- Use with caution in patients with glaucoma or prostatic hypertrophy
Warnings
- May cause drowsiness, use caution when operating machinery or driving
Others
- Avoid alcohol while taking dicycloverine hydrochloride due to increased drowsiness