Dienogest
Generic Details
Generic Name
Dienogest
Other Names
- Dinagest
- Dienogestum
Drug Class
- Progestin
- Progestogen
Chemical Formula
C20H25NO2
Molecular Weight
311.42 g/mol
Mechanism of Action
- Selective progesterone receptor modulator
Indications
- Endometriosis
- Heavy menstrual bleeding
- Menstrual disorders
Common Dosage Forms
- Tablet
Typical Dosage
- 2 mg once daily
Pediatric Dosage
Geriatric Dosage
Side Effects
- Headache
- Nausea
- Breast pain
- Irregular menstrual bleeding
- Mood changes
Contraindications
- Pregnancy
- Breastfeeding
- Liver disease
- Thromboembolic disorders
Pregnancy Category
- Category X - Contraindicated in pregnancy
Lactation Safety
- Not recommended during breastfeeding
Drug Interactions
- CYP3A4 inducers/inhibitors
Overdose Symptoms
- Nausea
- Vomiting
- Breast tenderness
Antidote for Overdose
- No specific antidote, treatment is symptomatic
Storage Conditions
- Store at room temperature away from moisture and heat
Pharmacokinetics
- Absorption: Well absorbed after oral administration
- Distribution: Highly protein bound
- Metabolism: Hepatic metabolism via CYP3A4
- Excretion: Primarily in feces
Precautions
- Monitor liver function tests
- Monitor for signs/symptoms of thromboembolic events
Warnings
- Increased risk of thromboembolism
- May increase the risk of breast cancer
Others
- May be used as a hormonal contraceptive in combination with estradiol