Difluprednate

Generic Name

Difluprednate

Other Names

• Durezol

Drug Class

• Corticosteroid

Chemical Formula

C27H34F2O7

Molecular Weight

504.55 g/mol

Mechanism of Action

• Difluprednate is a corticosteroid that works by reducing inflammation and suppressing the immune response in the targeted tissues.

Indications

• Treatment of inflammation and pain associated with ocular surgery
• Allergic conjunctivitis
• Uveitis

Common Dosage Forms

• Ophthalmic suspension

Typical Dosage

• Instill one drop into the conjunctival sac of the affected eye(s) four times daily for 2 weeks, then taper according to the physician's instruction.

Pediatric Dosage

• Safety and efficacy not established in children

Geriatric Dosage

• No specific dosage adjustments required

Side Effects

• Increased intraocular pressure
• Blurred vision
• Eye pain
• Eyelid edema
• Conjunctival hyperemia

Contraindications

• Hypersensitivity to difluprednate or any component of the formulation

Pregnancy Category

• Category C - use with caution

Lactation Safety

• Use with caution; not extensively studied in lactating women

Drug Interactions

• No significant drug interactions reported

Overdose Symptoms

• Unlikely with ophthalmic use, but prolonged use may lead to systemic effects of corticosteroids

Antidote for Overdose

• No specific antidote; treatment is symptomatic

Storage Conditions

• Store at controlled room temperature between 15°C to 25°C (59°F to 77°F)

Pharmacokinetics

• Absorption: Well absorbed through the ocular tissues
• Distribution: Metabolized in the liver
• Metabolism: Metabolized to inactive metabolites
• Excretion: Primarily excreted in the urine

Precautions

• Monitor for increases in intraocular pressure
• Regular eye examinations are recommended

Warnings

• Prolonged use may result in glaucoma or cataracts development

Others

• Prior to using difluprednate, inform your healthcare provider about any current medications, allergies, or medical conditions you may have.