Diosmin + Hesperidin

Generic Name

Diosmin-Hesperidin

Other Names

• Micronized Purified Flavonoid Fraction (MPFF)

Drug Class

• Vasoprotective agent
• Venotonic agent

Chemical Formula

C28H32O15 - Diosmin, C28H34O15 - Hesperidin

Molecular Weight

610.54 g/mol - Diosmin, 610.57 g/mol - Hesperidin

Mechanism of Action

• Improves venous tone and capillary resistance
• Reduces inflammation and oxidative stress in blood vessels
• Enhances lymphatic drainage

Indications

• Chronic venous insufficiency
• Hemorrhoids
• Varicose veins
• Edema
• Lymphedema

Common Dosage Forms

• Tablets
• Capsules

Typical Dosage

• 1-2 tablets/capsules daily, with meals

Pediatric Dosage

• Not established

Geriatric Dosage

• Dose adjustment may be necessary based on individual patient factors.

Side Effects

• Gastrointestinal upset (nausea, stomach cramps)
• Headache
• Dizziness
• Allergic reactions (rash, itching)

Contraindications

• Hypersensitivity to diosmin-hesperidin or any component of the formulation

Pregnancy Category

• Category C - Safety not established, consult healthcare provider before use

Lactation Safety

• Safety not established, consult healthcare provider before use

Drug Interactions

• Limited known interactions, but consult healthcare provider if taking other medications

Overdose Symptoms

• Limited data available, may include worsening of side effects

Antidote for Overdose

• No specific antidote, symptomatic treatment recommended

Storage Conditions

• Store at room temperature away from moisture and heat

Pharmacokinetics

• Absorption: Well-absorbed from the gastrointestinal tract
• Distribution: Distributed to various body tissues
• Metabolism: Metabolized in the liver
• Excretion: Excreted mainly in the urine

Precautions

• Use with caution in patients with liver or kidney impairment
• Monitor for any signs of allergic reactions

Warnings

• Discontinue use if any signs of severe allergic reactions occur

Others

• May take several weeks to see full benefits in chronic conditions.