Dobutamine Hydrochloride
Generic Details
Generic Name
Dobutamine
Other Names
- Dobutrex
Drug Class
- Beta-1 adrenergic agonist
Chemical Formula
C18H23NO3
Molecular Weight
301.38 g/mol
Mechanism of Action
- Selective agonist of beta-1 adrenergic receptors, leading to increased myocardial contractility
Indications
- Heart failure with reduced ejection fraction
- Cardiogenic shock
Common Dosage Forms
- Injection
Typical Dosage
- 2.5 to 10 mcg/kg/min
Pediatric Dosage
- 1 to 5 mcg/kg/min
Geriatric Dosage
- Lower initial doses and slower titration may be required
Side Effects
- Tachycardia
- Arrhythmias
- Hypotension
- Headache
- Nausea
Contraindications
- Hypersensitivity to dobutamine
- Hypertrophic obstructive cardiomyopathy
- Uncontrolled tachyarrhythmias
Pregnancy Category
- C
Lactation Safety
- Not recommended during breastfeeding
Drug Interactions
- Monoamine oxidase inhibitors (MAOIs)
- Tricyclic antidepressants
- General anesthetics
Overdose Symptoms
- Severe hypertension
- Arrhythmias
- Seizures
Antidote for Overdose
- Beta-blockers like propranolol
Storage Conditions
- Store at room temperature away from light and moisture
Pharmacokinetics
- Absorption: Rapidly metabolized in the liver
- Distribution: Distributes into extravascular spaces
- Metabolism: Metabolized mainly in the liver
- Excretion: Excreted in the urine as metabolites
Precautions
- Use with caution in patients with arrhythmias
- Close monitoring of heart rate and blood pressure is essential
Warnings
- Should be administered by healthcare professionals experienced in the management of acute cardiovascular conditions
Others
- May cause false-positive results in doping tests due to its structural similarity to clenbuterol