Docetaxel Trihydrate
Generic Details
Generic Name
Docetaxel Trihydrate
Other Names
- Taxotere
- Docecad
- DTX
- Docetaxel
Drug Class
- Taxane Chemotherapeutic
Chemical Formula
C43H53NO14 • 3H2O
Molecular Weight
807.879 g/mol
Mechanism of Action
- Microtubule Inhibitor
- Promotes microtubule assembly and stabilizes microtubules, leading to cell cycle arrest and inhibition of cell division
Indications
- Breast Cancer
- Lung Cancer
- Prostate Cancer
- Stomach Cancer
- Head and Neck Cancer
Common Dosage Forms
- Concentrate for solution for infusion
Typical Dosage
- 60-100 mg/m2 infused over 1 hour every 3 weeks
Pediatric Dosage
- Safety and efficacy not established in pediatric patients
Geriatric Dosage
- Dose adjustment may be necessary in elderly patients
Side Effects
- Neutropenia
- Febrile Neutropenia
- Anemia
- Fatigue
- Fluid Retention
- Nausea
- Vomiting
- Diarrhea
- Mucositis
- Peripheral Neuropathy
- Hair Loss
Contraindications
- Hypersensitivity to docetaxel or polysorbate 80
- Severe liver impairment
Pregnancy Category
- D - Potential risk to the fetus, use in pregnant women only if benefits outweigh risks
Lactation Safety
- Not recommended during breastfeeding
Drug Interactions
- CYP3A4 inducers/inhibitors
- P-glycoprotein substrates
Overdose Symptoms
- Severe neutropenia
- Peripheral neurotoxicity
- Mucositis
Antidote for Overdose
- No specific antidote, manage symptoms and provide supportive care
Storage Conditions
- Store vials at controlled room temperature (20-25°C)
Pharmacokinetics
- Absorption: IV administration, complete
- Distribution: Extensive distribution into tissues
- Metabolism: Hepatic metabolism via CYP3A4
- Excretion: Mainly biliary excretion
Precautions
- Monitor blood counts regularly
- Use with caution in patients with liver or kidney impairment
Warnings
- Hypersensitivity reactions
- Severe myelosuppression
- Fluid retention
Others
- It is important to administer premedication to prevent hypersensitivity reactions before each infusion.