Domperidone Maleate

Generic Details

Generic Name

Domperidone-Maleate

Other Names

  • Domperidone

Drug Class

  • Dopamine antagonist
  • Prokinetic agent

Chemical Formula

Molecular Weight

Mechanism of Action

  • Blocks dopamine receptors in the brain and upper intestine, leading to increased contractions of the stomach and intestines.

Indications

  • Nausea and vomiting
  • Dyspepsia
  • Gastroparesis
  • Reflux esophagitis

Common Dosage Forms

  • Tablet
  • Oral suspension

Typical Dosage

  • 10 mg to 20 mg 3 to 4 times a day before meals and at bedtime

Pediatric Dosage

  • The usual dose is 0.25-0.5 mg/kg body weight, up to a maximum of 40 mg daily

Geriatric Dosage

  • Dosage adjustments may be needed due to decreased liver, kidney, or heart function in elderly patients

Side Effects

  • Headache
  • Dizziness
  • Dry mouth
  • Abdominal cramps
  • Diarrhea

Contraindications

  • Known hypersensitivity to domperidone
  • Gastrointestinal bleeding
  • Prolactin-releasing pituitary tumor (prolactinoma)

Pregnancy Category

  • Not adequately studied in pregnant women. Use only if the potential benefit justifies the potential risk to the fetus.

Lactation Safety

  • Domperidone may pass into breast milk. Caution is advised when used during breastfeeding.

Drug Interactions

  • Strong CYP3A4 inhibitors and QT-prolonging drugs

Overdose Symptoms

  • Agitation
  • Somnolence
  • Convulsions

Antidote for Overdose

  • No specific antidote, treatment is supportive and symptomatic

Storage Conditions

  • Store at room temperature (15-30°C)

Pharmacokinetics

  • Absorption: Rapidly absorbed from the gastrointestinal tract
  • Distribution: Widely distributed throughout the body
  • Metabolism: Metabolized in the liver
  • Excretion: Mainly in the urine and feces

Precautions

  • Use with caution in patients with hepatic impairment
  • Regular monitoring of electrocardiogram (ECG) may be needed due to potential QT prolongation

Warnings

  • Risk of serious cardiac arrhythmias, especially in patients taking other medications that prolong the QT interval

Others

  • Can be used to stimulate lactation in nursing mothers by increasing prolactin levels