Almitrine Bismesylate + Raubasine
Generic Details
Generic Name
Almitrine-Bismesylate-Raubasine
Other Names
- Almitrine
- Bismesylate
- Raubasine
Drug Class
- Respiratory Stimulant
- Vasodilator
- Cerebral Circulation Enhancer
Chemical Formula
Molecular Weight
Mechanism of Action
- Almitrine-Bismesylate enhances ventilation-perfusion matching by stimulating ventilation in hypoxic pulmonary regions.
- Raubasine acts as a cerebral vasodilator, increasing blood flow to the brain.
Indications
- Chronic obstructive pulmonary disease (COPD)
- Intermittent claudication
- Memory and cognitive disorders
Common Dosage Forms
- Tablet
- Solution for Injection
Typical Dosage
- Almitrine-Bismesylate: 100-200 mg orally per day
- Raubasine: 20-40 mg orally per day
Pediatric Dosage
Geriatric Dosage
Side Effects
- Nausea
- Headache
- Dizziness
- Gastrointestinal disturbances
Contraindications
- Hypersensitivity to any component of the formulation
Pregnancy Category
- Not recommended during pregnancy
Lactation Safety
- Use with caution while breastfeeding
Drug Interactions
- Monoamine oxidase inhibitors (MAOIs)
- Antihypertensive agents
Overdose Symptoms
- Hypotension
- Tachycardia
- Nausea
- Vomiting
Antidote for Overdose
Storage Conditions
- Store in a cool, dry place away from light
Pharmacokinetics
- Absorption:
- Distribution:
- Metabolism:
- Excretion:
Precautions
- Use with caution in patients with hepatic impairment
- Monitor blood pressure regularly during treatment
Warnings
- Avoid abrupt withdrawal in patients on long-term therapy