Doxophylline
Generic Details
Generic Name
doxophylline
Other Names
- Chronophylline
Drug Class
- Bronchodilator
- Methylxanthine
Chemical Formula
C7H7N5O2
Molecular Weight
189.16 g/mol
Mechanism of Action
- Phosphodiesterase inhibitor
- Adenosine receptor antagonist
Indications
- Chronic obstructive pulmonary disease (COPD)
- Bronchial asthma
Common Dosage Forms
- Tablet
- Syrup
Typical Dosage
- 400mg once daily in the morning
Pediatric Dosage
- Dosage based on weight and age, under medical supervision
Geriatric Dosage
- Reduced dose may be required due to decreased renal function
Side Effects
- Nausea
- Vomiting
- Headache
- Palpitations
- Dizziness
Contraindications
- Hypersensitivity to doxophylline
- Severe cardiac arrhythmias
Pregnancy Category
- Category C - Risk cannot be ruled out
Lactation Safety
- Limited data, caution advised
Drug Interactions
- Cimetidine
- Fluvoxamine
- Ciprofloxacin
Overdose Symptoms
- Severe nausea
- Vomiting
- Seizures
- Cardiac arrhythmias
Antidote for Overdose
- Symptomatic treatment and supportive care
Storage Conditions
- Store in a cool, dry place away from direct sunlight
Pharmacokinetics
- Absorption: Rapidly absorbed after oral administration
- Distribution: Widely distributed throughout the body
- Metabolism: Metabolized in the liver
- Excretion: Primarily excreted in the urine
Precautions
- Patients with liver or kidney impairment
- Monitor cardiac function during therapy
Warnings
- Avoid abrupt withdrawal to prevent exacerbation of symptoms
Others
- May cause caffeine-like stimulation