Doxycycline Hydrochloride
Generic Details
Generic Name
Doxycycline Hydrochloride
Other Names
- Vibramycin
- Doryx
- Adoxa
Drug Class
- Tetracycline Antibiotic
Chemical Formula
C22H24N2O8.HCl
Molecular Weight
480.9 g/mol
Mechanism of Action
- Inhibits bacterial protein synthesis by binding to the 30S ribosomal subunit
Indications
- Acne
- Respiratory tract infections
- Urinary tract infections
- Sexually transmitted infections
- Lyme disease
Common Dosage Forms
- Capsules
- Tablets
- Syrup
Typical Dosage
- 100 mg - 200 mg per day, taken in 1 or 2 divided doses
Pediatric Dosage
- Dosing based on weight and severity of infection
Geriatric Dosage
- Adjust dosage based on renal function
Side Effects
- Nausea
- Vomiting
- Diarrhea
- Photosensitivity
- Tooth discoloration in children
Contraindications
- Hypersensitivity to tetracyclines
- Pregnancy after the 15th week
Pregnancy Category
- D
Lactation Safety
- Usually compatible with breastfeeding in short-term use
Drug Interactions
- Antacids, iron supplements, warfarin, penicillins
Overdose Symptoms
- Nausea
- Vomiting
- Diarrhea
- Intracranial hypertension
Antidote for Overdose
- No specific antidote, mainly supportive care
Storage Conditions
- Store at room temperature, protect from light and moisture
Pharmacokinetics
- Absorption: Well absorbed orally
- Distribution: Distributed widely in body tissues
- Metabolism: Hepatic
- Excretion: Primarily in feces, some in urine
Precautions
- Avoid sunlight exposure
- Take with plenty of water to prevent esophageal irritation
Warnings
- Not recommended for use in children under 8 years
- Can cause permanent tooth discoloration in developing teeth
Others
- May interfere with certain lab tests (e.g., urine catecholamines)