Drospirenone + Ethinylestradiol (0.02 mg)

Generic Details

Generic Name

Drospirenone-Ethinylestradiol 0.02 mg

Other Names

  • Drospirenone-Ethinyl Estradiol 0.02 mg
  • Yaz 0.02 mg
  • Gianvi 0.02 mg

Drug Class

  • Combined Oral Contraceptive

Chemical Formula

C24H30O3 - C24H30O2

Molecular Weight

366.49 g/mol - 372.52 g/mol

Mechanism of Action

  • Inhibition of ovulation
  • Thickening of cervical mucus
  • Alteration of endometrium

Indications

  • Contraception
  • Acne vulgaris in women seeking contraception
  • Premenstrual dysphoric disorder (PMDD)

Common Dosage Forms

  • Oral Tablet

Typical Dosage

  • 1 tablet daily for 28 days, starting on the first day of menstruation

Pediatric Dosage

  • Not recommended for pediatric use

Geriatric Dosage

  • Use with caution in geriatric patients

Side Effects

  • Nausea
  • Headache
  • Breast tenderness
  • Irregular bleeding
  • Mood changes
  • Weight changes

Contraindications

  • Pregnancy
  • Severe liver disease
  • History of blood clots

Pregnancy Category

  • Category X - Contraindicated in pregnancy

Lactation Safety

  • Generally Compatible with breastfeeding

Drug Interactions

  • Antibiotics (e.g., Rifampin)
  • Anticonvulsants (e.g., Carbamazepine)
  • St. John's Wort

Overdose Symptoms

  • Nausea
  • Vomiting
  • Vaginal bleeding

Antidote for Overdose

  • No specific antidote, manage symptoms

Storage Conditions

  • Store at room temperature away from moisture and heat

Pharmacokinetics

  • Absorption: Rapidly absorbed from the gastrointestinal tract
  • Distribution: Protein-bound, distributed in tissues
  • Metabolism: Metabolized in the liver
  • Excretion: Excreted in urine and feces

Precautions

  • Monitor for signs of thromboembolism
  • Regular blood pressure checks
  • Monitor for mood changes

Warnings

  • Increased risk of blood clots
  • Cigarette smoking increases cardiovascular risk in women over 35 years old

Others

  • May improve menstrual cycle regularity
  • May reduce menstrual cramps