Drotaverine Hydrochloride

Generic Details

Generic Name

Drotaverine Hydrochloride

Other Names

  • Drotaverine HCl
  • No-Spa

Drug Class

  • Antispasmodic

Chemical Formula

C24H26N2O4

Molecular Weight

398.47 g/mol

Mechanism of Action

  • Inhibition of phosphodiesterase enzyme
  • Calcium channel modulation

Indications

  • Treatment of smooth muscle spasms in gastrointestinal, biliary, and genitourinary systems

Common Dosage Forms

  • Tablet
  • Injection

Typical Dosage

  • 40-80 mg orally thrice daily

Pediatric Dosage

  • Safety and efficacy not established in children

Geriatric Dosage

  • Dosage adjustment may be needed due to decreased metabolism

Side Effects

  • Dizziness
  • Headache
  • Nausea
  • Vomiting
  • Dry mouth

Contraindications

  • Hypersensitivity to drotaverine
  • Severe hepatic impairment

Pregnancy Category

  • Category C - Animal reproduction studies have shown an adverse effect on the fetus

Lactation Safety

  • Use with caution while breastfeeding

Drug Interactions

  • Avoid concomitant use with other antispasmodics
  • May enhance the effects of alcohol and CNS depressants

Overdose Symptoms

  • Severe dizziness
  • Hypotension
  • Tachycardia

Antidote for Overdose

  • Symptomatic and supportive treatment

Storage Conditions

  • Store at room temperature (15-30°C)
  • Protect from light and moisture

Pharmacokinetics

  • Absorption: Well absorbed after oral administration
  • Distribution: Widely distributed in the body
  • Metabolism: Metabolized in the liver
  • Excretion: Mainly excreted in the urine

Precautions

  • Caution in patients with renal impairment
  • Monitor for signs of hypotension

Warnings

  • Avoid abrupt discontinuation
  • May cause drowsiness