Mesalazine [5-aminosalicylic acid]
Generic Details
Generic Name
Mesalazine (5-aminosalicylic acid)
Other Names
- 5-ASA
- Mesalamine
Drug Class
- Aminosalicylates
Chemical Formula
C7H7NO3
Molecular Weight
153.14 g/mol
Mechanism of Action
- Exact mechanism in inflammatory bowel disease is not entirely understood, but thought to involve modulation of inflammatory mediators.
Indications
- Ulcerative colitis
- Crohn's disease
Common Dosage Forms
- Tablet
- Capsule
- Suppository
- Enema
Typical Dosage
- 400-800 mg orally 3-6 times daily
Pediatric Dosage
- Dosage based on weight and age, consult healthcare provider
Geriatric Dosage
- Dose adjustment may be necessary, consult healthcare provider
Side Effects
- Nausea
- Headache
- Abdominal pain
- Diarrhea
- Hair loss
Contraindications
- Hypersensitivity to salicylates
- Severe renal impairment
Pregnancy Category
- Category B - Animal reproduction studies have failed to demonstrate a risk to the fetus.
Lactation Safety
- Limited data available, use with caution and consult healthcare provider
Drug Interactions
- Warfarin
- Azathioprine
- Lactulose
Overdose Symptoms
- Confusion
- Seizures
- Hypersensitivity reactions
Antidote for Overdose
- No specific antidote, manage symptoms and provide supportive care
Storage Conditions
- Store at room temperature away from moisture and heat
Pharmacokinetics
- Absorption: Absorbed in the small intestine
- Distribution: Distributed to the colon
- Metabolism: Metabolized in the liver to N-acetyl-5-aminosalicylic acid
- Excretion: Excreted mainly in the urine
Precautions
- Monitor renal function regularly
- Monitor for signs of allergic reactions
Warnings
- May worsen symptoms of colitis if not properly managed
- Monitor for signs of pancreatitis
Others
- It is important to follow the prescribed dosing schedule regularly for optimal effectiveness.