Dydrogesterone
Generic Details
Generic Name
Dydrogesterone
Other Names
- Duphaston
- Duphalyte
- Dufaston
- Gynorest
- Dydroboon
- Dupoestrin
Drug Class
- Progestogen
Chemical Formula
C21H28O2
Molecular Weight
312.445 g/mol
Mechanism of Action
- Selective progesterone receptor modulator
Indications
- Treatment of menstrual disorders
- Support of luteal phase in assisted reproductive techniques
- Endometriosis management
- Premenstrual syndrome
- Menopausal hormone therapy
Common Dosage Forms
- Oral tablets
- Oral capsules
Typical Dosage
- 10 mg to 20 mg per day, usually for 5 to 10 days
Pediatric Dosage
- Not recommended in children
Geriatric Dosage
- Dose adjustment may be needed in elderly patients
Side Effects
- Headache
- Nausea
- Breast tenderness
- Menstrual spotting
- Weight changes
- Mood changes
Contraindications
- Hypersensitivity to dydrogesterone or any component of the formulation
- Undiagnosed vaginal bleeding
- Breast cancer
- Liver dysfunction
Pregnancy Category
- Not recommended during pregnancy, especially during the first trimester
Lactation Safety
- Compatible with breastfeeding, caution advised
Drug Interactions
- May interact with CYP3A4 inducers or inhibitors
- May interact with drugs that are substrates of P-glycoprotein
Overdose Symptoms
- Nausea
- Vomiting
- Fatigue
- Breast tenderness
Antidote for Overdose
- No specific antidote, treatment is symptomatic and supportive
Storage Conditions
- Store at room temperature (20-25°C)
- Protect from moisture and light
Pharmacokinetics
- Absorption: Rapidly absorbed following oral administration
- Distribution: Well-distributed in the body, extensively bound to plasma proteins
- Metabolism: Metabolized mainly in the liver
- Excretion: Eliminated primarily in the feces
Precautions
- Monitor liver function during therapy
- Monitor for signs of thromboembolic disorders
Warnings
- Increased risk of venous thromboembolism
- Discontinue if jaundice or liver dysfunction occurs
Others
- May help in the prevention of recurrent miscarriages