Ebastine
Generic Details
Generic Name
Ebastine
Other Names
- Ebastel
- Kestine
Drug Class
- Second-generation antihistamine
- Non-sedating antihistamine
Chemical Formula
C32H39NO2
Molecular Weight
469.66 g/mol
Mechanism of Action
- Competitive histamine H1-receptor antagonist
Indications
- Allergic rhinitis
- Chronic idiopathic urticaria
Common Dosage Forms
- Tablet
- Oral Solution
Typical Dosage
- 10 mg once daily
Pediatric Dosage
- 2-6 years: 5 mg once daily
- 6-12 years: 10 mg once daily
Geriatric Dosage
- No specific dosage adjustments recommended
Side Effects
- Headache
- Dry mouth
- Fatigue
- Drowsiness
Contraindications
- Hypersensitivity to Ebastine or any component of the formulation
- Severe hepatic impairment
Pregnancy Category
- Category C
Lactation Safety
- Limited data in lactation, caution advised
Drug Interactions
- Erythromycin (may increase Ebastine levels)
- Ketoconazole (may increase Ebastine levels)
Overdose Symptoms
- Sedation
- Tachycardia
Antidote for Overdose
- No specific antidote, treatment is symptomatic and supportive
Storage Conditions
- Store at room temperature (15-30°C)
- Protect from light and moisture
Pharmacokinetics
- Absorption: Rapidly absorbed from the gastrointestinal tract
- Distribution: Highly protein-bound, mainly to albumin
- Metabolism: Undergoes extensive hepatic metabolism to active metabolite carebastine
- Excretion: Primarily eliminated in the urine and feces
Precautions
- Caution in patients with severe renal impairment
- Caution in patients with epilepsy or at risk of seizures
Warnings
- Avoid use in patients with severe hepatic impairment
- May cause drowsiness, caution when driving or operating machinery