Econazole Nitrate
Generic Details
Generic Name
Econazole Nitrate
Other Names
Drug Class
- Antifungal
Chemical Formula
C18H15Cl3N2O
Molecular Weight
381.69 g/mol
Mechanism of Action
- Econazole inhibits the synthesis of ergosterol, a key component of fungal cell membranes, disrupting membrane permeability and leading to cell death.
Indications
- Treatment of fungal infections such as ringworm, athlete's foot, jock itch, and yeast infections.
Common Dosage Forms
- Cream
- Lotion
- Solution
Typical Dosage
- Apply a thin layer of cream or lotion on the affected area twice daily for 2-4 weeks.
Pediatric Dosage
- Consult healthcare provider for appropriate dosage in children.
Geriatric Dosage
- Dose adjustment may be required in elderly patients, consult healthcare provider.
Side Effects
- Common side effects include itching, redness, burning, irritation at the application site.
Contraindications
- Hypersensitivity to econazole or any components of the formulation.
Pregnancy Category
- Category C - Animal reproduction studies have shown an adverse effect on the fetus, and there are no adequate and well-controlled studies in pregnant women.
Lactation Safety
- Use with caution in nursing mothers, consult healthcare provider.
Drug Interactions
- No significant drug interactions reported.
Overdose Symptoms
- Unlikely with topical application, in case of accidental ingestion, seek medical help.
Antidote for Overdose
- No specific antidote, symptomatic treatment recommended.
Storage Conditions
- Store at room temperature away from moisture and heat.
Pharmacokinetics
- Absorption: Minimal systemic absorption after topical application.
- Distribution: Limited information available.
- Metabolism: Primarily hepatic metabolism.
- Excretion: Excreted in feces and urine.
Precautions
- Avoid contact with eyes, nose, mouth, and mucous membranes.
Warnings
- For external use only, not for ophthalmic use.