Eplerenone
Generic Details
Generic Name
Eplerenone
Other Names
- Inspra
Drug Class
- Mineralocorticoid receptor antagonist
Chemical Formula
C24H30O6S
Molecular Weight
414.55 g/mol
Mechanism of Action
- Selective aldosterone blocker
Indications
- Hypertension
- Heart failure post-myocardial infarction
Common Dosage Forms
- Tablet
Typical Dosage
- 50 mg to 100 mg once daily
Pediatric Dosage
Geriatric Dosage
- Start with lower doses due to age-related decrease in renal function
Side Effects
- Hyperkalemia
- Dizziness
- Fatigue
- Headache
Contraindications
- Hyperkalemia
- Severe renal impairment
- Addison's disease
Pregnancy Category
- C
Lactation Safety
- Not Recommended
Drug Interactions
- Potassium-sparing diuretics
- ACE inhibitors
- NSAIDs
Overdose Symptoms
- Hyperkalemia
- Hypotension
Antidote for Overdose
- Administration of loop diuretics or glucose and insulin
Storage Conditions
- Store at room temperature away from moisture and heat
Pharmacokinetics
- Absorption: Rapidly absorbed from the gastrointestinal tract
- Distribution: Highly bound to plasma proteins
- Metabolism: Metabolized by CYP3A4
- Excretion: Primarily excreted in feces and urine
Precautions
- Regular monitoring of potassium levels
- Avoid in patients with moderate to severe hepatic impairment
Warnings
- Potential for hyperkalemia, especially in patients with renal impairment or on concomitant use of potassium supplements
Others
- May cause gynecomastia in males