Eplerenone

Generic Details

Generic Name

Eplerenone

Other Names

  • Inspra

Drug Class

  • Mineralocorticoid receptor antagonist

Chemical Formula

C24H30O6S

Molecular Weight

414.55 g/mol

Mechanism of Action

  • Selective aldosterone blocker

Indications

  • Hypertension
  • Heart failure post-myocardial infarction

Common Dosage Forms

  • Tablet

Typical Dosage

  • 50 mg to 100 mg once daily

Pediatric Dosage

    Geriatric Dosage

    • Start with lower doses due to age-related decrease in renal function

    Side Effects

    • Hyperkalemia
    • Dizziness
    • Fatigue
    • Headache

    Contraindications

    • Hyperkalemia
    • Severe renal impairment
    • Addison's disease

    Pregnancy Category

    • C

    Lactation Safety

    • Not Recommended

    Drug Interactions

    • Potassium-sparing diuretics
    • ACE inhibitors
    • NSAIDs

    Overdose Symptoms

    • Hyperkalemia
    • Hypotension

    Antidote for Overdose

    • Administration of loop diuretics or glucose and insulin

    Storage Conditions

    • Store at room temperature away from moisture and heat

    Pharmacokinetics

    • Absorption: Rapidly absorbed from the gastrointestinal tract
    • Distribution: Highly bound to plasma proteins
    • Metabolism: Metabolized by CYP3A4
    • Excretion: Primarily excreted in feces and urine

    Precautions

    • Regular monitoring of potassium levels
    • Avoid in patients with moderate to severe hepatic impairment

    Warnings

    • Potential for hyperkalemia, especially in patients with renal impairment or on concomitant use of potassium supplements

    Others

    • May cause gynecomastia in males