Erythromycin (Oral)
Generic Details
Generic Name
Erythromycin-oral
Other Names
- E-Mycin
- Eryc
- Ery-Tab
- Erythrocin
Drug Class
- Macrolide Antibiotic
Chemical Formula
C37H67NO13
Molecular Weight
733.93 g/mol
Mechanism of Action
- Inhibits protein synthesis by binding to the 50S ribosomal subunit of susceptible organisms.
Indications
- Respiratory tract infections
- Skin infections
- Acne
- Chlamydia infections
- Legionnaires' disease
- Prophylaxis of rheumatic fever
Common Dosage Forms
- Tablet
- Capsule
- Suspension
Typical Dosage
- 250-500 mg every 6 hours
Pediatric Dosage
- Dosage based on weight and severity of infection
Geriatric Dosage
- Generally lower doses due to decreased renal function
Side Effects
- Nausea
- Vomiting
- Abdominal pain
- Diarrhea
- Allergic reactions (rash, itching)
- Hearing loss (rare)
Contraindications
- Hypersensitivity to erythromycin
- Concomitant use with certain CYP3A4 inhibitors
Pregnancy Category
- Category B - No evidence of risk in humans
Lactation Safety
- Compatible with breastfeeding
Drug Interactions
- CYP3A4 inhibitors can increase erythromycin levels
- May increase serum levels of theophylline, carbamazepine, and digoxin
Overdose Symptoms
- Severe nausea
- Vomiting
- Dehydration
Antidote for Overdose
- No specific antidote, treatment is supportive
Storage Conditions
- Store at room temperature (15-30°C)
Pharmacokinetics
- Absorption: Well absorbed orally
- Distribution: Widely distributed in body tissues
- Metabolism: Partially metabolized in the liver
- Excretion: Excreted mainly in bile and urine
Precautions
- Use with caution in patients with liver disease
- Monitor for signs of superinfection during prolonged use
Warnings
- Risk of QT prolongation and ventricular arrhythmias
- Report any signs of hearing loss immediately
Others
- Caution in patients with myasthenia gravis due to potential neuromuscular blockade