Naproxen Sodium + Esomeprazole Magnesium

Generic Details

Generic Name

Naproxen Sodium + Esomeprazole Magnesium

Other Names

  • Naproxen + Esomeprazole

Drug Class

  • Nonsteroidal Anti-Inflammatory Drug (NSAID) + Proton Pump Inhibitor (PPI)

Chemical Formula

C28H22MgN4O9S2

Molecular Weight

660.89 g/mol

Mechanism of Action

  • Naproxen: Inhibits COX enzymes, reducing prostaglandin synthesis
  • Esomeprazole: Reduces gastric acid secretion by irreversibly inhibiting the H+/K+ ATPase pump

Indications

  • Symptomatic treatment of osteoarthritis, rheumatoid arthritis, ankylosing spondylitis
  • Reduction of risk of NSAID-associated gastric ulcers

Common Dosage Forms

  • Tablet

Typical Dosage

  • 1 tablet (500 mg naproxen + 20 mg esomeprazole) twice daily

Pediatric Dosage

  • Safety and efficacy not established in children

Geriatric Dosage

  • Adjust dosage based on individual patient needs

Side Effects

  • Nausea
  • Headache
  • Diarrhea
  • Abdominal pain
  • Dizziness

Contraindications

  • Hypersensitivity to NSAIDs, PPIs, or any component of the formulation

Pregnancy Category

  • Category D - Avoid use in the third trimester

Lactation Safety

  • Use with caution while breastfeeding

Drug Interactions

  • Warfarin, SSRIs, other NSAIDs

Overdose Symptoms

  • Gastric bleeding, metabolic acidosis, renal failure

Antidote for Overdose

  • Supportive care, activated charcoal if recent ingestion

Storage Conditions

  • Store at room temperature away from moisture and heat

Pharmacokinetics

  • Absorption: Rapid and complete absorption from the gastrointestinal tract
  • Distribution: Protein-bound and widely distributed in the body
  • Metabolism: Hepatic metabolism via CYP enzymes
  • Excretion: Renal excretion of metabolites

Precautions

  • History of gastrointestinal bleeding or ulcers

Warnings

  • Increased risk of cardiovascular events, gastrointestinal bleeding