Estriol (Oral)

Generic Details

Generic Name

Estriol-oral

Other Names

  • Estriol tablets
  • Oral estriol

Drug Class

  • Estrogen

Chemical Formula

C18H24O3

Molecular Weight

288.38 g/mol

Mechanism of Action

  • Estriol acts as an agonist at estrogen receptors, exerting its effects by regulating gene transcription.

Indications

  • Estrogen deficiency symptoms in menopausal women
  • Vaginal dryness and atrophy
  • Postmenopausal osteoporosis prevention

Common Dosage Forms

  • Oral tablets

Typical Dosage

  • 1-2 mg daily

Pediatric Dosage

  • Not established

Geriatric Dosage

  • Adjusted based on individual patient needs

Side Effects

  • Nausea
  • Breast tenderness
  • Headache
  • Abnormal vaginal bleeding

Contraindications

  • Pregnancy
  • Breast cancer
  • Liver disease

Pregnancy Category

  • Category X - Contraindicated in pregnancy

Lactation Safety

  • Compatible with breastfeeding in low doses

Drug Interactions

  • Warfarin
  • Rifampin
  • St. John's Wort

Overdose Symptoms

  • Nausea
  • Vomiting
  • Vaginal bleeding

Antidote for Overdose

  • No specific antidote

Storage Conditions

  • Store at room temperature between 20-25°C (68-77°F)

Pharmacokinetics

  • Absorption: Well absorbed from the gastrointestinal tract
  • Distribution: Binds to sex hormone-binding globulin
  • Metabolism: Primarily hepatic
  • Excretion: Mainly urine

Precautions

  • Monitor lipid levels
  • Regular gynecological examinations

Warnings

  • Increased risk of endometrial cancer
  • Cardiovascular risks associated with long-term use

Others

  • Estriol may provide benefits for vaginal health and urinary symptoms during menopause.