Almotriptan
Generic Details
Generic Name
Almotriptan
Other Names
- Axert
Drug Class
- Triptan
Chemical Formula
C17H25N3O2
Molecular Weight
291.4 g/mol
Mechanism of Action
- Selective agonist for serotonin (5-HT1B/1D) receptors
Indications
- Acute treatment of migraine with or without aura in adults
Common Dosage Forms
- Tablet
Typical Dosage
- 12.5 mg or 25 mg orally, as needed
Pediatric Dosage
- Not established
Geriatric Dosage
- Consider lower starting dose
Side Effects
- Dizziness
- Nausea
- Somnolence
- Paresthesia
- Dry mouth
Contraindications
- Hypersensitivity to almotriptan
- Uncontrolled hypertension
- Ischemic heart disease
Pregnancy Category
- C - Risk cannot be ruled out
Lactation Safety
- Not recommended, excreted in breast milk
Drug Interactions
- Ergot-containing drugs
- MAO inhibitors
- SSRIs
Overdose Symptoms
- Drowsiness
- Tremor
- Hypertension
Antidote for Overdose
- Supportive care
Storage Conditions
- Store at room temperature away from light and moisture
Pharmacokinetics
- Absorption: Rapidly absorbed after oral administration
- Distribution: Crosses the blood-brain barrier
- Metabolism: Primarily hepatic via CYP3A4
- Excretion: Mainly in the urine
Precautions
- History of stroke or transient ischemic attack
- Severe hepatic impairment
Warnings
- Risk of myocardial ischemia/infarction and other cardiac events
Others
- Almotriptan is not intended for the prevention of migraines.