Etoricoxib
Generic Details
Generic Name
Etoricoxib
Other Names
- Arcoxia
Drug Class
- Nonsteroidal anti-inflammatory drug (NSAID)
Chemical Formula
C18H15ClN2O2S
Molecular Weight
358.8 g/mol
Mechanism of Action
- Selective inhibition of cyclooxygenase-2 (COX-2) enzyme
Indications
- Osteoarthritis
- Rheumatoid arthritis
- Ankylosing spondylitis
- Acute gout
- Acute pain
Common Dosage Forms
- Tablet
- Oral suspension
Typical Dosage
- 60 to 120 mg once daily for osteoarthritis and rheumatoid arthritis
Pediatric Dosage
- Not recommended for use in children under 16 years of age
Geriatric Dosage
- Dose adjustment may be required in elderly patients
Side Effects
- Gastritis
- Peptic ulcers
- Edema
- Headache
- Dizziness
- Hypertension
- Heart failure
Contraindications
- Hypersensitivity to NSAIDs
- Active peptic ulcer
- Severe heart failure
Pregnancy Category
- Category C - Risk cannot be ruled out
Lactation Safety
- Not recommended during breastfeeding due to limited data
Drug Interactions
- Warfarin
- Aspirin
- ACE inhibitors
- Lithium
Overdose Symptoms
- Nausea
- Vomiting
- Stomach pain
- Dizziness
- Drowsiness
Antidote for Overdose
- Supportive care and symptomatic treatment
Storage Conditions
- Store at room temperature away from moisture and heat
Pharmacokinetics
- Absorption: Well absorbed after oral administration
- Distribution: Highly protein-bound
- Metabolism: Extensively metabolized in the liver
- Excretion: Mainly excreted in the urine
Precautions
- Monitor for signs of gastrointestinal bleeding
- Use with caution in renal impairment
Warnings
- Increased risk of cardiovascular events
- Risk of gastrointestinal bleeding and ulcers
Others
- Avoid excessive or prolonged use due to cardiovascular and gastrointestinal risks