Famotidine
Generic Details
Generic Name
Famotidine
Other Names
- Pepcid
- Heartburn Relief
Drug Class
- H2 receptor antagonist
Chemical Formula
C8H15N7O2S3
Molecular Weight
337.43 g/mol
Mechanism of Action
- Blocks the action of histamine at the H2 receptors of the stomach, reducing the production of stomach acid.
Indications
- Heartburn
- Acid indigestion
- Gastroesophageal reflux disease (GERD)
- Peptic ulcers
Common Dosage Forms
- Tablet
- Oral suspension
Typical Dosage
- 20-40 mg once or twice daily
Pediatric Dosage
- Consult with a healthcare provider
Geriatric Dosage
- Dosage adjustments may be needed in elderly patients
Side Effects
- Headache
- Dizziness
- Constipation
- Diarrhea
- Fatigue
Contraindications
- Hypersensitivity to famotidine or other H2-receptor antagonists
Pregnancy Category
- Category B - Safe for use during pregnancy
Lactation Safety
- Considered safe during breastfeeding
Drug Interactions
- Antacids may reduce the effectiveness of famotidine
Overdose Symptoms
- Confusion
- Rapid heart rate
- Fainting
Antidote for Overdose
- Symptomatic and supportive treatment
Storage Conditions
- Store at room temperature away from moisture and heat
Pharmacokinetics
- Absorption: Rapidly absorbed from the gastrointestinal tract
- Distribution: Widely distributed in the body
- Metabolism: Metabolized in the liver
- Excretion: Excreted mainly in the urine
Precautions
- Monitor renal function in patients with impaired kidney function
Warnings
- Use with caution in patients with a history of kidney problems
Others
- May be available over-the-counter for short-term relief of heartburn