Febuxostat
Generic Details
Generic Name
Febuxostat
Other Names
- Uloric
Drug Class
- Xanthine Oxidase Inhibitor
Chemical Formula
C16H16N2O3S
Molecular Weight
316.37 g/mol
Mechanism of Action
- Inhibits xanthine oxidase enzyme, thereby decreasing uric acid production
Indications
- Chronic management of hyperuricemia in gout
- Prevention of gout flares
Common Dosage Forms
- Tablet
Typical Dosage
- 40-80 mg once daily
Pediatric Dosage
- Not established
Geriatric Dosage
- Dose adjustment may be needed for renal impairment
Side Effects
- Nausea
- Arthralgia
- Rash
- Liver function abnormalities
Contraindications
- Severe liver disease
- History of severe hypersensitivity reaction to febuxostat
Pregnancy Category
- C - Risk cannot be ruled out
Lactation Safety
- Use with caution
Drug Interactions
- Azathioprine
- Mercaptopurine
- Theophylline
Overdose Symptoms
- Nausea
- Vomiting
- Diarrhea
Antidote for Overdose
- Symptomatic and supportive treatment
Storage Conditions
- Store at room temperature away from moisture and heat
Pharmacokinetics
- Absorption: Well absorbed after oral administration
- Distribution: Extensively distributed in the body
- Metabolism: Hepatic metabolism
- Excretion: Mainly renal excretion
Precautions
- Monitor liver function tests regularly
- Monitor for signs of hypersensitivity reactions
Warnings
- Hepatotoxicity risk
- Cardiovascular events risk
Others
- Febuxostat may increase the risk of cardiovascular thromboembolic events.